The curriculum at St. Anthony Catholic School ensures strong academic expectations and the development of the whole child. The curriculum is delivered through lesson plans designed to meet students' unique social, physical, emotional, and academic needs.

The curriculum meets the standard requirements of the TCCB-ED, Texas Catholic Conference of Bishops Education Department, State of Texas - Texas Essential Knowledge and Skills (TEKS) as well as the objectives set forth in the curriculum guides adopted by the School Department of the Diocese of Brownsville. The Principal observes and works closely with classroom teachers to serve the needs of all students. The core curriculum is supported by a variety of enrichment classes and programs to support student learning.